Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Identifieur interne : 000068 ( France/Analysis ); précédent : 000067; suivant : 000069Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
Auteurs : Cristine Alves Da Costa [France] ; Claire Sunyach [France] ; Emilie Giaime [France] ; Andrew West [États-Unis] ; Olga Corti [France] ; Alexis Brice [France] ; Stephen Safe [États-Unis] ; Patrick M. Abou-Sleiman [Royaume-Uni] ; Nicholas W. Wood [Royaume-Uni] ; Hitoshi Takahashi [Japon] ; Mathew S. Goldberg [États-Unis] ; Jie Shen [États-Unis] ; Frdric Checler [France]Source :
- Nature Cell Biology [ 1465-7392 ] ; 2009-11.
Abstract
Parkin, an ubiquitin ligase whose mutations are associated with early development of Parkinson's disease, possesses a RING domain, suggesting it can modulate transcription. Parkin represses the expression of p53 both in fibroblasts and mice brains, independently of its ligase activity, and patient brain samples exhibit high levels of p53.
Url:
DOI: 10.1038/ncb1981
Affiliations:
- France, Japon, Royaume-Uni, États-Unis
- Maryland, Massachusetts, Provence-Alpes-Côte d'Azur, Île-de-France
- Paris, Valbonne
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 000A34
- to stream Main, to step Curation: 000903
- to stream Main, to step Exploration: 000927
- to stream France, to step Extraction: 000068
Links to Exploration step
ISTEX:C676C95926166904C35FC41DA35F19CC55E260C2Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease</title><author><name sortKey="Da Costa, Cristine Alves" sort="Da Costa, Cristine Alves" uniqKey="Da Costa C" first="Cristine Alves" last="Da Costa">Cristine Alves Da Costa</name></author><author><name sortKey="Sunyach, Claire" sort="Sunyach, Claire" uniqKey="Sunyach C" first="Claire" last="Sunyach">Claire Sunyach</name></author><author><name sortKey="Giaime, Emilie" sort="Giaime, Emilie" uniqKey="Giaime E" first="Emilie" last="Giaime">Emilie Giaime</name></author><author><name sortKey="West, Andrew" sort="West, Andrew" uniqKey="West A" first="Andrew" last="West">Andrew West</name></author><author><name sortKey="Corti, Olga" sort="Corti, Olga" uniqKey="Corti O" first="Olga" last="Corti">Olga Corti</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name></author><author><name sortKey="Abou Sleiman, Patrick M" sort="Abou Sleiman, Patrick M" uniqKey="Abou Sleiman P" first="Patrick M." last="Abou-Sleiman">Patrick M. Abou-Sleiman</name></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name></author><author><name sortKey="Goldberg, Mathew S" sort="Goldberg, Mathew S" uniqKey="Goldberg M" first="Mathew S." last="Goldberg">Mathew S. Goldberg</name></author><author><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name></author><author><name sortKey="Checler, Frdric" sort="Checler, Frdric" uniqKey="Checler F" first="Frdric" last="Checler">Frdric Checler</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C676C95926166904C35FC41DA35F19CC55E260C2</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1038/ncb1981</idno><idno type="url">https://api.istex.fr/document/C676C95926166904C35FC41DA35F19CC55E260C2/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A34</idno><idno type="wicri:Area/Main/Curation">000903</idno><idno type="wicri:Area/Main/Exploration">000927</idno><idno type="wicri:Area/France/Extraction">000068</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease</title><author><name sortKey="Da Costa, Cristine Alves" sort="Da Costa, Cristine Alves" uniqKey="Da Costa C" first="Cristine Alves" last="Da Costa">Cristine Alves Da Costa</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Valbonne</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Sunyach, Claire" sort="Sunyach, Claire" uniqKey="Sunyach C" first="Claire" last="Sunyach">Claire Sunyach</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Valbonne</settlement></placeName></affiliation></author><author><name sortKey="Giaime, Emilie" sort="Giaime, Emilie" uniqKey="Giaime E" first="Emilie" last="Giaime">Emilie Giaime</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Valbonne</settlement></placeName></affiliation></author><author><name sortKey="West, Andrew" sort="West, Andrew" uniqKey="West A" first="Andrew" last="West">Andrew West</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Corti, Olga" sort="Corti, Olga" uniqKey="Corti O" first="Olga" last="Corti">Olga Corti</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U679, Hpital de la Piti-Salptrire, 47 boulevard de l'Hpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U679, Hpital de la Piti-Salptrire, 47 boulevard de l'Hpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Environmental & Genetic Medicine, Institute of Biosciences & Technology, Houston</wicri:regionArea><wicri:noRegion>Houston</wicri:noRegion></affiliation></author><author><name sortKey="Abou Sleiman, Patrick M" sort="Abou Sleiman, Patrick M" uniqKey="Abou Sleiman P" first="Patrick M." last="Abou-Sleiman">Patrick M. Abou-Sleiman</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Brain Research Institute, University of Niigata, 1-757 Asahimachi, Niigata 951-8585</wicri:regionArea><wicri:noRegion>Niigata 951-8585</wicri:noRegion></affiliation></author><author><name sortKey="Goldberg, Mathew S" sort="Goldberg, Mathew S" uniqKey="Goldberg M" first="Mathew S." last="Goldberg">Mathew S. Goldberg</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center of Neurological Diseases, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name><affiliation wicri:level="2"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center of Neurological Diseases, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Checler, Frdric" sort="Checler, Frdric" uniqKey="Checler F" first="Frdric" last="Checler">Frdric Checler</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Pharmacologie Molculaire et Cellulaire and Institut de NeuroMdecine Molculaire, UMR6097 CNRS/UNSA, quipe labellise Fondation pour la Recherche Mdicale, 660 Route des Lucioles, 06560, Valbonne</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Valbonne</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Cell Biology</title><idno type="ISSN">1465-7392</idno><idno type="eISSN">1476-4679</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="2009-11">2009-11</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1370">1370</biblScope><biblScope unit="page" to="1375">1375</biblScope></imprint><idno type="ISSN">1465-7392</idno></series><idno type="istex">C676C95926166904C35FC41DA35F19CC55E260C2</idno><idno type="DOI">10.1038/ncb1981</idno><idno type="ArticleID">ncb1981</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1465-7392</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Parkin, an ubiquitin ligase whose mutations are associated with early development of Parkinson's disease, possesses a RING domain, suggesting it can modulate transcription. Parkin represses the expression of p53 both in fibroblasts and mice brains, independently of its ligase activity, and patient brain samples exhibit high levels of p53.</div></front></TEI><affiliations><list><country><li>France</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li><li>Provence-Alpes-Côte d'Azur</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Valbonne</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Da Costa, Cristine Alves" sort="Da Costa, Cristine Alves" uniqKey="Da Costa C" first="Cristine Alves" last="Da Costa">Cristine Alves Da Costa</name></region><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Checler, Frdric" sort="Checler, Frdric" uniqKey="Checler F" first="Frdric" last="Checler">Frdric Checler</name><name sortKey="Checler, Frdric" sort="Checler, Frdric" uniqKey="Checler F" first="Frdric" last="Checler">Frdric Checler</name><name sortKey="Corti, Olga" sort="Corti, Olga" uniqKey="Corti O" first="Olga" last="Corti">Olga Corti</name><name sortKey="Da Costa, Cristine Alves" sort="Da Costa, Cristine Alves" uniqKey="Da Costa C" first="Cristine Alves" last="Da Costa">Cristine Alves Da Costa</name><name sortKey="Giaime, Emilie" sort="Giaime, Emilie" uniqKey="Giaime E" first="Emilie" last="Giaime">Emilie Giaime</name><name sortKey="Sunyach, Claire" sort="Sunyach, Claire" uniqKey="Sunyach C" first="Claire" last="Sunyach">Claire Sunyach</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="West, Andrew" sort="West, Andrew" uniqKey="West A" first="Andrew" last="West">Andrew West</name></region><name sortKey="Goldberg, Mathew S" sort="Goldberg, Mathew S" uniqKey="Goldberg M" first="Mathew S." last="Goldberg">Mathew S. Goldberg</name><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name><name sortKey="Shen, Jie" sort="Shen, Jie" uniqKey="Shen J" first="Jie" last="Shen">Jie Shen</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Abou Sleiman, Patrick M" sort="Abou Sleiman, Patrick M" uniqKey="Abou Sleiman P" first="Patrick M." last="Abou-Sleiman">Patrick M. Abou-Sleiman</name></noRegion><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></country><country name="Japon"><noRegion><name sortKey="Takahashi, Hitoshi" sort="Takahashi, Hitoshi" uniqKey="Takahashi H" first="Hitoshi" last="Takahashi">Hitoshi Takahashi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000068 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000068 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:C676C95926166904C35FC41DA35F19CC55E260C2
|texte= Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |